Nanoparticles may harm the brain

first_imgA simple change in electric charge may make the difference between someone getting the medicine they need and a trip to the emergency room—at least if a new study bears out. Researchers investigating the toxicity of particles designed to ferry drugs inside the body have found that carriers with a positive charge on their surface appear to cause damage if they reach the brain.These particles, called micelles, are one type of a class of materials known as nanoparticles. By varying properties such as charge, composition, and attached surface molecules, researchers can design nanoparticles to deliver medicine to specific body regions and cell types—and even to carry medicine into cells. This ability allows drugs to directly target locations they would otherwise be unable to, such as the heart of tumors. Researchers are also looking at nanoparticles as a way to transport drugs across the blood-brain barrier, a wall of tightly connected cells that keeps most medication out of the brain. Just how safe nanoparticles in the brain are, however, remains unclear.So Kristina Bram Knudsen, a toxicologist at the National Research Centre for the Working Environment in Copenhagen, and colleagues tested two types of micelles, which were made from different polymers that gave the micelles either a positive or negative surface charge. They injected both versions, empty of drugs, into the brains of rats, and 1 week later they checked for damage. Three out of the five rats injected with the positively charged micelles developed brain lesions. The rats injected with the negatively charged micelles or a saline control solution did not suffer any observable harm from the injections, the team will report in an upcoming issue of Nanotoxicology.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Knudsen speculates that one of the attributes that makes positive micelles and similar nanoparticles such powerful drug delivery systems may also be what is causing the brain damage. Because cells have a negative charge on their outside, they attract positively charged micelles and bring them into the cell. The micelles’ presence in the cell or alteration of the cell’s surface charge, she says, may disrupt the cell’s normal functioning.Negatively charged nanoparticles can also enter cells, according to other research. However, they do so less readily and must be able to overcome the repulsion between themselves and the cell surface. It is possible that the reason the negatively charged micelles were not found to be toxic was that they did not invade cells to the same extent as the positively charged micelles. The findings are intriguing, says biomedical engineer Jordan Green of Johns Hopkins University in Baltimore, Maryland. But he cautions that there is no evidence that all positively charged nanoparticles behave this way. Other factors can also play a role in the toxicity of nanoparticles, adds pharmaceutical expert Jian-Qing Gao of Zhejiang University in Hangzhou, China. The size and concentration of the particles, as well as the strain of rat used, could all have influenced the results, he says.last_img read more

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Davis Cup: India have mountain to climb against top seeds Czech Republic

first_imgIndia will challenge Davis Cup powerhouse and top seeds Czech Republic for a place in the elite World Group, hoping that their players will capitalise on home conditions and absence of world number six Tomas Berdych in the Play-off tie, beginning here tomorrow.The fact that Berdych is missing from the rival line-up has prevented it from becoming a one-sided contest but the patchy form of Somdev Devvarman is still a cause of concern for the hosts.The results in the last few months for one of the most hard-working Indian players are far from encouraging. There were 11 instances when Somdev failed to clear the first round and four times he did not go beyond second round in the main draw matches, including the Challengers.Lack of hard work has never been a problem for Somdev but his defensive style of play, which he has stubbornly refused to change, is perhaps the bane of his game.That puts Yuki Bhambri, who is in decent touch and has acquired the status of country’s numero uno singles player, under a lot of pressure.Yuki had emerged India’s hero in the tie against New Zealand where he won both his matches, including the deciding fifth rubber. Here too, a lot would depend on how the 23-year-old handles pressure of playing against superior players.He is in red-hot form and is coming into the tie after winning the Shanghai Challenger title, which has seen his world ranking rise to 125.Yuki will open the tie for India by playing against Lukas Rosol before Somdev takes on Jiri Vesley.advertisement”I would prefer playing in cooler conditions but I can play freely at 0-0,” Yuki said after the draw.But Somdev enjoys an unbeaten record on the slow DLTA courts. He has not lost a single match here since 2010, winning a Commonwealth Games gold and two Delhi Open titles.If he can continue his love-affair with the venue, he will do great service to the nation.The venue too has been chosen by the players themselves, keeping in mind the slow nature of the conditions that suit the Indians. The ball comes slow and bounces on the centre court, which would mean that points won’t finish fast. This is exactly what Somdev loves.But at the same time searing heat may trouble the Indians too and keeping themselves cramps-free would be crucial. The temperature is likely to be around 35-36 and the fitness of the players of both the sides will be tested.last_img read more

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GST bill likely to be approved this year: Morgan Stanley

first_imgNew Delhi, May 12 (PTI) The Goods and Services Tax (GST) bill is likely to be passed in the coming months and is expected to be implemented sometime next year, says a Morgan Stanley report. The global financial services major said in a research note that market expectations with regard to passage of the GST bill have waned. “Therefore, the passage of the bill in the upcoming sessions would be viewed positively.” In recent times, investor expectations regarding the passage of the GST bill, have waned due to a logjam in the Upper House. “GST has the potential to benefit large companies as their warehousing costs decline and tax liabilities level off with unorganised players,” the report said adding that investors are focused on the new GST law, so its clearance could be important to equities. Meanwhile, Finance Minister Arun Jaitley has sought to reach out to Congress in the Rajya Sabha after the main opposition party said it was ready to give full support to GST provided its three key recommendations are accepted by the government. Jaitley said he will be holding talks again with the Congress leaders so that the bill could be taken up in the Monsoon session. The GST Bill, though approved by the Lok Sabha, is held up in the Rajya Sabha where the ruling NDA does not have a majority. PTI DRR SAlast_img read more

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India vs Pakistan, turning points: Jasprit Bumrah’s costly no-ball, Virat Kohli’s failure vs Amir

first_imgFollowing are five key moments that helped Pakistan win the Champions Trophy for the first time with a crushing 180-run victory over holders India at The Oval on Sunday.Pakistan captain Sarfraz Ahmed loses toss:India have done well chasing down targets so captain Virat Kohli opted to put his rivals in to bat first.It proved to be a good toss to lose as Sarfraz said he would also have elected to field if he had won it.”We wanted to bowl first. But the toss is out of our control. Hopefully, we can post more than 300,” Sarfraz said.Pakistan opener Fakhar Zaman is caught by Mahendra Singh Dhoni for three – off a no ball:With his bat tucked under his arm, Fakhar begins the long walk back to the pavilion as the Indians celebrate grabbing their first wicket with only four Pakistan runs on the board.The celebrations swiftly change direction, however, when replays on the big scoreboard show that Jasprit Bumrah had bowled a no ball and Fakhar is called back to the crease.It proved to be a costly no ball as Fakhar goes on to score his first international century before falling for 114.Kohli fails to capitalise on a dropped catch on five:The Indian captain had come into the match with an astonishing batting average of 253 runs in this year’s tournament, having been dismissed only once in four matches.So when he was dropped by Azhar Ali in the slips off Mohammad Amir in the third over, huge cheers erupted around the arena. Pakistan made sure it did not turn out to be a costly mistake, though, as Amir dismissed him next ball.advertisementHis departure proved to be a bad omen for the Indians as the only other time he had been dismissed in this year’s Champions Trophy – against Sri Lanka in the group stage – the holders also lost the match.Amir back in the team after missing semi-final with back injury:Amir, once vilified for his role in the 2010 Pakistan spot-fixing scandal which led to him serving a prison term in London, was at his brilliant best when he produced a devastating opening spell.He removed India’s top three batsmen – Rohit Sharma (0), Shikhar Dhawan (21) and Kohli (5).After leaving India reeling on six for two following the dismissals of Sharma and Kohli, Amir’s figures read 1.4 overs, four runs, two wickets.His transformation into a hero was complete as his final tally was six overs, two maidens, 16 runs and three wickets.Hardik Pandya, India’s last hope, run out for 76 after showering the ground with sixes:Pandya came to the crease with India teetering on 54 for five after Yuvraj Singh and former captain Dhoni departed in quick succession.He raised hopes of pulling off a one-man Indian Houdini act as he hit three successive sixes to reach his half century. But just when it seemed that he was blazing towards a first international century, he was run out after a mix-up with Ravindra Jadeja.India still had three wickets in hand but the deafening cheers from the Pakistan fans made clear that the end was nigh.India lost their last four wickets for the addition of only six runs.last_img read more

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Galatasaray stuns host Olympiacos with comeback victory (video)

first_imgGalatasaray Odeabank Istanbul showed its great pride again in stunning fashion on Friday by roaring from behind to defeat Olympiacos Piraeus 71-80 on the road in Greece. It marked the second time since it was eliminated from the playoffs race that Galatasaray defeated a top-three team in the standings, after its home win over Real Madrid two rounds ago. This time, Galatasaray shook off a 15-point deficit right after halftime to outscore playoff-bound Olympiacos 21-45 the rest of the way and sweep its two games against the Reds this season. Galatasaray improved to 9-17 and moved up to 13th place, while Olympiacos fell to 18-8 and at least delayed its objective of securing home-court advantage in the playoffs. Vladimir Micov hit 4 of 5 three-pointers, including back-to-back game-deciders in the last 2 minutes, to lead the winners with 18 points. He also had 5 rebounds, 5 assists and 4 steals. Alex Tyus followed with 14 and Goksenin Koksal 13 for Galatasaray, which made 10 of 16 threes as compared to 2 of 20 for Olympiacos. The Reds got 14 points each from Erick Green and Georgios Printezis but otherwise failed to capitalize on their big early lead which was built on the first dozen of a club record 22 offensive rebounds.Micov made a jumper off a steal to open the scoring before a put-back by Printezis tied the score. Austin Daye scored over the backboard but Khem Birch matched him before a free throws by Vassilis Spanoulis gave Olympiacos its first lead, 5-4. Printezis finished a three-point play on the break and Spanoulis scored again as the lead quickly hit 10-4. Sinan Guler found Tibor Pleiss for a slam and hit the game’s first triple at 12-9. Pleiss and Kostas Papanikolaou traded inside baskets before the latter dunked to finish a fastbreak. Spanoulis fed Nikola Milutinov next as the lead hit 20-11. Printezis pirouetted for another basket before Bruno Fitipaldo hit a triple that Green matched for Olympiacos as the hosts took a 27-14 lead after 10 minutes. Fitipaldo struck from deep again to open the second quarter, but Dimitris Agravanis took a highway to the basket and completed a three-point play at 30-17. Tyus slammed an alley-oop in style but Green’s back-to-back baskets extended the difference to 34-19. Koksal hit free throws and fed Tyus for another dunk, but a third-chance possession by Olympiacos, which already had 11 offensive rebounds, ended in a dunk by Birch. The exchange of baskets continued non-stop to 44-32 as Ege Arar and Can Korkmaz combined on 6 quick points for the visitors. Spanoulis answered with a layup and free throws as Olympiacos went ahead 48-35 at the break.Papanikolaou fed Milutinov as Olympiacos reached 50 points to start the second half. A looping alley-oop dunk by Pleiss was followed by Printezis and Koksal scoring on the break, then Papanikolaou scored easily inside to make it 54-39. Galatasaray continued making things happen with Koksal scoring 8 quick points to cut the difference to 55-46. Guler cut it further from downtown as Olympiacos kept missing until Dominic Waters appeared with his first basket at 57-49. Daye answered with a two-pointer and Micov stepped out for a triple to suddenly make it a three-point game. Galatasaray’s comeback was complete when Daye buried a transition triple to complete a 2-11 run to make it 57-57. Only another jumper by Waters let Olympiacos escape with a 59-57 advantage after 30 minutes. A tip-in by Tyus opened the fourth quarter and then he dunked a feed from Micov for Galatasaray’s first lead since the opening minutes, 59-61. Matt Lojeski responded with a three-point play for Olympiacos and then Green hit a runner in the lane to settle the hosts at 64-61. But Micov was ready with a tough triple to tie again, 64-64, with 7 minutes left. Micov then made a pair go-ahead baskets around a put-back dunk by Patric Young for a 66-68 scoreboard with 4 minutes left. Spanoulis set up Green for an open triple, just the second of the night for Olympiacos, to retake the lead, but Guler took it right back with a driving layup at 69-70. Then Micov kept stroking from the arc with back-to-back blasts from the same spot for a 69-76 advantage with 1:14 left. Printezis ended almost 3 scoreless minutes by Olympiacos with free throws, but only 52 seconds remained. Daye hit just 1 of 4 free throws for the visitors, ending his personal streak of 27 in a row made, but Olympiacos kept missing it shots as Galatasaray kept adding to its lead for a season sweep of the Reds.Source: EuroleagueTweetPinShare0 Shareslast_img read more

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Dortmund slam ‘disrespectful’ Wenger over Auba claims

first_imgTransfers Arsenal’s Aubameyang talk branded ‘disrespectful’ by disappointed Dortmund Chris Burton Last updated 1 year ago 20:53 1/18/18 FacebookTwitterRedditcopy Comments(8) Pierre-Emerick Aubameyang Borussia Dortmund.jpg Getty Images Transfers Arsenal Borussia Dortmund Bundesliga Premier League Pierre-Emerick Aubameyang African All Stars Michael Zorc, sporting director at the Bundesliga club, has told Arsene Wenger to spend more time worrying about his own players than possible targets Arsene Wenger’s willingness to discuss Arsenal’s links to Pierre-Emerick Aubameyang is “disrespectful”, says Borussia Dortmund sporting director Michael Zorc.The Gunners boss was quizzed once again on Thursday about his reported interest in the prolific Gabon international.He refused to go into detail regarding a mooted approach but also ruled nothing out, telling reporters: “This kind of thing is better when it is secret. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player “You announce it when it is over the line. Nothing else is close.”Unsurprisingly, those comments have not gone down well in Dortmund.The Bundesliga outfit are reluctant to part with a prized asset during the January transfer window, even if they have faced disciplinary issues with Aubameyang of late.Zorc, then, has taken the opportunity to hit out at Wenger, with the Arsenal manager urged to spend more time worrying about his own players than possible transfer targets – with the likes of Alexis Sanchez and Mesut Ozil still providing unwelcome distractions at Emirates Stadium.Pierre-Emerick Aubameyang“We consider it disrespectful to speak about players from other clubs,” Zorc told reporters on the Aubameyang rumours.“There is no contact with Arsenal.“We assume that Wenger has enough to do dealing with his own players.”While Dortmund are eager to curb the speculation surrounding Aubameyang, Arsenal are likely to be in the market for attacking inspiration during the current window.Sanchez is edging ever close to securing a switch to Manchester United, while Olivier Giroud has been mentioned as a possible makeweight in a raid on Signal Iduna Park.Wenger is certainly keeping his options open, with the Frenchman having added when pressed on whether Aubameyang’s personality would be right for the Gunners: “Yes, a character can be very positive or very negative.“Overall you look at achievement over career and if he has done well the character has been used in a positive way.”Aubameyang has netted 21 times in just 23 appearances this season, with the 28-year-old’s remarkable return for Dortmund now standing at 141 goals in 212 outings.last_img read more

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Gabrielle Union Explains Why Dwyane Wade Had To Become A Nebraska Fan

first_img Via the Omaha World-Herald:Union said her father was at first skeptical about Wade.“I had been married before — spoiler alert — and I had to write some checks after that one,” Union said, “So my dad was watching the wallet, and he was like ‘What do you want with her? She’s got her own life, she’s got her own house, she’s got her own stuff, what are you bringing to the table?’”[…]Union said her father made him a deal: “If you’ll commit to being a Nebraska Cornhusker fan, I’ll let you in the family.”“We have not missed a home opener, yet.” Union said before cheering, “GO BIG RED!”As Union said, the couple has been a presence at Husker football games. Nebraska basketball also offered a scholarship to his son, Zaire Wade, last summer, though the status of that offer is unclear with the recent coaching change.Given the excitement around the Scott Frost era entering year two, and Wade might’ve gotten in ahead of the bandwagon at a good time. Dwyane Wade and Gabrielle Union cheer on Nebraska football.LINCOLN, NE – SEPTEMBER 23: Basketball star Dwyane Wade and actress Gabrielle Union greet fans during a break in the game between the Nebraska Cornhuskers and the Rutgers Scarlet Knights at Memorial Stadium on September 23, 2017 in Lincoln, Nebraska. (Photo by Steven Branscombe/Getty Images)Dwayne Wade famously went to Marquette, where he is likely the greatest player in program history. In 2003, he almost single-handedly led the Golden Eagles to the Final Four.Luckily for him, his alma mater doesn’t have a football program. That was big when it came to wooing his wife Gabrielle Union.Union is a Nebraska native, and a life long, diehard Huskers fan. Based on a recent interview, things may not have worked out if Wade wasn’t willing to adopt the Huskers himself.Gabrielle Union recently appeared on The Late Late Show With James Corden, and told the story of why Dwyane Wade has to embrace her Nebraska fandom.Essentially, it was a major way that he could win her father over.last_img read more

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UP Mahagathbandhan fails to stop Modi wave

first_imgLucknow: The Bharatiya Janata Party has won comfortable victory in Uttar Pradesh, the state where it created a record by winning 71 of 80 Lok Sabha seats in 2014. The BJP managed to neutralise the combined force of Samajwadi Party, Bahujan Samaj Party Mahagathbandhan and the Congress-led UPA. The BJP was ahead on 62 seats, SP+BSP on 15 and Congress on just one seat till reports last filtered in. PM Narendra Modi has retained Varanasi seat.last_img

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Women ridership may go up by 50 on scheme execution CM

first_imgNEW DELHI: Delhi Chief Minister Arvind Kejriwal on Wednesday asserted that the DMRC has predicted that after the implementation for Free Metro Travel for Women scheme nearly 50 percent hike in women ridership would be expected.”The DMRC has submitted a concrete proposal on our scheme to make public transport free for women. The DMRC has said it expects a 50 per cent increase in women ridership after the roll out of this scheme, which means 45-50% of the ridership will be women. This will mean a total financial commitment of Rs 1566.64 crore,” said the Chief Minister. Also Read – Kejriwal ‘denied political clearance’ to attend climate meet in DenmarkCM Kejriwal added that two options have been proposed by the Delhi Metro Railway Corporation (DMRC) for the implementation of this scheme. One is a long term plan which would take one year to implement and will involve changing the DMRC’s software, tokens and cards. However, the second option is a shorter stop-gap arrangement. “As per this model, women shall be able to purchase tokens at ticket windows and automatic ticket vending machines (ATVMs) by simply sharing their destination. There will be a separate entry gate for women with this token, but their exit gates will remain common. The DMRC will not need to change their software,” said the Delhi Chief Minister. Also Read – Bangla Sahib Gurudwara bans use of all types of plastic itemsHe further said that the DMRC has proposed that it would need 8 months to roll out this model. “we believe we can work with their officers and implement the scheme in the next 2-3 months. Only two steps need to be taken by the DMRC – special tokens need to be printed and in 170 stations where ticket windows have been shut, they need to be reopened. We do not think these steps will take more than 2-3 months,” said CM Kejriwal. Meanwhile, in this letter, the DMRC also observed that the proposal of this scheme should be passed by the Fare Fixation Committee which would have members of the Center and also state government. “The Fare Fixation Committee should ordinarily not be required in this case because this is not a matter of fare fixation. However, if the DMRC thinks it is necessary, we will go ahead with it.” When asked about whether the policy was discriminatory, CM Kejriwal said, “To those who say this policy is against gender equality, I ask – Do we have gender equality in this country, to begin with? We do not live in a country that treats women at par with men. Only 30 per cent of the Metro ridership is women. Women form only 11 per cent of Delhi’s workforce, whereas the national average is 24 per cent. This needs to change. The kind of opportunities that will open up for women if their travel becomes free is enormous. It will boost their status as members of the workforce and boost the economy.”last_img read more

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Get ready for anything trade lawyer tells business community on NAFTA

first_imgOTTAWA – Growing uncertainty over the future of the North American Free Trade Agreement means companies need to brace themselves, including for the possibility that President Donald Trump walks away from a deal, a trade lawyer is warning the business community.“The first step is for companies to understand this is very real and that they need to start contingency planning,” said Dan Ujczo, an international trade lawyer specializing in Canada-U.S. matters.On the campaign trail last year, candidate Trump vowed to rip up NAFTA — the 23-year-old trade agreement between the U.S., Canada and Mexico — if he could not renegotiate a better deal.His recent reiterations of that threat, along with demands Canada and Mexico consider impossible, have forced everyone to take it more seriously.It remains to be seen whether Trump will in fact attempt to withdraw, how U.S. Congress would react, whether Mexico and Canada would still keep talking and what that would end up meaning, in real terms, for cross-border trade between the three countries.The U.S. business and agriculture community has been ramping up its efforts to convince Congress, which could use its legislative powers to make it harder for Trump to exit the agreement, that they are not on board with abandoning the deal.That outreach is important, Ujczo told businesses during an online presentation Friday, but it is also not too early to get ready for any outcome.There are some practical matters to consider, such as taking a look at the supply chain to determine how exposed a business would become if some of the tougher proposals, such as stricter rules of origin for the materials used in auto manufacturing, come to pass.That should include examining checking certificates of origin and maintaining scrupulous records, because both client companies and customs officials are likely to start applying greater scrutiny as they also get ready for the new way of doing things.“It’s time to really buckle down and take a look at that, because these proposals are going to heighten awareness throughout the supply chain and at the borders,” Ujczo, who is with the cross-border firm Dickinson Wright, in Columbus, Ohio, said during the presentation.The lawyer also had advice for companies thinking about outsourcing to Asia as a way to minimize the fallout from the NAFTA renegotiations.“Keep in mind NAFTA is not the only thing the Trump administration is doing. It’s targeting Asia,” said Ujczo, who noted the U.S. has been ramping up its trade enforcement activities all around the world. “The only way the Trump trade strategy works is as a one-two punch: tightening up North America, while also targeting goods coming in from overseas.”That raises the question of whether Canadian companies should think about packing up and moving south.Ujczo said that would not be the case for everyone, but if they have U.S. customers, it makes financial sense and the company was already thinking about moving there someday, it might not be a bad idea to speed up those plans.“It has to have some business rationale,” he said in an interview. “I would never recommend just setting up shop in the U.S. if you don’t have any other business going on there,” he said, but if it was already on the horizon: “It would accelerate that life cycle.”Brenda Swick, a Toronto-based international trade lawyer with Dickinson Wright who joined the presentation, was more cautious.“I think they should stay put where they are right now, but they should be looking at plan B,” she said in an interview.Swick said those back-up plans should include figuring out how a company would be effected if there was a new NAFTA, a bilateral agreement between Canada and the U.S., or no free trade agreement between the two countries at all.— Follow @smithjoanna on Twitterlast_img read more

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Former PM Harper offers help on trade but staying neutral in UK

first_imgFormer prime minister Stephen Harper says he’s willing to help the next British prime minister negotiate a divorce deal with the European Union — but he’s not taking sides in the race to decide who that is.Harper tweeted Saturday night that he’s “willing to assist whoever serves as the next leader of the UK Conservative Party on trade matters, should they wish.”But as the current chair of the International Democrat Union, an alliance of conservative-leaning political parties from across the globe, Harper says he must remain “neutral in all member party leadership races.”He was responding to a report in The Sunday Times newspaper that said British Conservative leadership candidate Jeremy Hunt had “drafted in two senior Canadian politicians” to help negotiate a Brexit deal.The Sunday Times reports that Hunt — one of just two remaining candidates to replace Theresa May as party leader and prime minister — has recruited Harper and former Conservative MP Rona Ambrose.Hunt tells the newspaper he’s intent on securing a so-called “Canada-plus” trade deal with the EU, based on the Comprehensive Economic and Trade Agreement primarily negotiated by Harper’s government.Neither Harper nor Ambrose immediately responded to a request for comment on Sunday.The Canadian Presslast_img read more

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Indias industrial growth slows to 17 in January

first_imgNew Delhi: Industrial output growth stood at 1.7 per cent in January on account of slowdown in the manufacturing sector. Factory output as measured in terms of the Index of Industrial Production (IIP) had grown by 7.5 per cent in January 2018. During April-January 2018-19, industrial output grew at 4.4 per cent as against 4.1 per cent in the same period previous fiscal, according to the data released by the Central Statistics Office (CSO) on Tuesday.last_img

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New Flyer wins contract to provide Edmonton with 110 clean diesel buses

WINNIPEG – New Flyer Industries Canada ULC has won a contract to provide the City of Edmonton with 110 clean diesel heavy-duty transit buses, as well as options by the city to purchase an additional 120 buses.The company says the buses will be deployed on the Edmonton Transit Service (ETS) network starting 2018, supporting routes that move more than 300,000 people per day.It says Edmonton’s replacement of aging fleet vehicles with more efficient, air-conditioned models is part of the city’s goal to transform riders’ transit experience.New Flyer (TSX:NFI) is the largest transit bus and motor coach manufacturer and parts distributor in North America.It has fabrication, manufacturing, distribution and service centres across Canada, employing more than 5,400 people.Its headquarters are in Winnipeg.“For over 20 years we have supported Edmonton’s innovative growth and development with New Flyer buses,” said Paul Soubry, president and CEO. “We are proud to support Edmonton’s continued transformation as it expands public transit infrastructure, and focuses on clean energy, sustainability, and safe, accessible public transportation.”The company also offers Motor Coach Industries (MCI) J-Series, the industry’s best-selling intercity coach for 11 consecutive years, and the MCI D-Series. New Flyer wins contract to provide Edmonton with 110 clean diesel buses by The Canadian Press Posted Aug 15, 2017 5:40 pm MDT Last Updated Aug 15, 2017 at 6:20 pm MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email read more

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Thesis defences — Feb 12 to 16

Biological Sciences MSc thesis defenceBiological Sciences student Lyndon Duff will defend his Master of Science thesis, “Reproductive behaviour of male Xylocopa virginica and the influence of body size, nestmates, and siblings on territory defense,” on Wednesday, Feb. 14 at 1 p.m. in Welch Hall 147.The examination committee includes Cheryl McCormick, Chair; Rebecca MacPherson, External Examiner; Miriam Richards, Supervisor; Ping Liang and Adonis Skandalis, committee members. The following is a list of thesis defences taking place at Brock from Feb. 12 to 16.All are open for the University community to attend.Critical Sociology MA thesis defenceCritical Sociology student, Hannah Monroe, will defend the thesis, “By talking about it we can make it a positive thing: Autistic people negotiating identity and understanding in discursive contexts,” on Monday, Feb. 12 at noon in Welch Hall 147.The examination committee includes Dawn Zinga, Chair; Hanna Bertilsdotter-Rosqvist, External Examiner (Umeå University, Sweden); Trent Newmeyer, supervisor; and Rebecca Raby and Danny Tarulli, committee members. read more

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With 300 Million In Play Floyd Mayweather Is Right

No bag can hold the money Floyd Mayweather will make in two weeksWhen you consider the almost incomprehensible financial windfall for this one fight, Floyd Mayweather is right: He and Manny Pacquiao are facing off at the right time. That’s what the money says, and money talks.Five or six years ago, when they were likely at the peak of their physical powers, a Mayweather-Pacquiao bout might have produced a more technically sound fight than what we will see in a fortnight. But they would not have earned the money they stand to gain from this fight.For example, on Monday, according to the The New York Times, promoter Bob Arum will transfer into a Pacquiao bank account $50 million. That’s a down payment, minus the IRS’ 30 percent cut.Leonard Ellerbe, CEO of Mayweather Productions, would not share specifics about his boss’ pay. But he said, “I will tell you this. Floyd Mayweather’s check will be a lot more than $50 million. And then it goes from there.”According to the contract, Mayweather is to receive 60 percent of the revenues to Pacquiao’s 40 percent. When all the pennies are calculated, both men will make more than $100 million, win or lose, which almost means no one loses. It will rank as the highest grossing fight in history, by double.That would not have happened six years ago. But the boxing public is so thirsty now, as the sport struggles with an identity, for star power, that the meeting of the two biggest names in the game is the uber fight of recent times.“This is a unique situation, the confluence of time and event — the two biggest fighters in the world coming together,” Ken Hershman, the president of HBO Sports, said to The Times.Ironically and significantly, the fight began to take shape after Mayweather and Pacquiao ran into each other at a Miami Heat NBA game in January. Mayweather set up another meeting the next day at his hotel and the richest fight in history was on.“We’re both bigger names than we were five, six years ago,” Mayweather said at his gym in Las Vegas on Tuesday. “We’re meeting at the pinnacle of our careers. The time is right.”Mayweather made about $105 million in two fights last year, bolting him to the world’s highest paid athlete status. To keep all the money straight for this fight, The Times reported, rivals HBO (Pacquiao) and Showtime (Mayweather) are co-producing and co-distributing the pay-per-view event in a rare agreement. They have created a central accounting system.“They distribute the revenue in accordance with the contracts of the two fighters, so that there is no side money,” Arum said. “We felt that this was the most reasonable way to go. It’s the way we’ve done it to prevent the accusations that we usually get, that this promoter is stealing from that promoter.”All revenue from the fight — the foreign broadcast rights, closed-circuit income from bars and theaters, ticket sales, sponsorships, merchandise sales and so on — goes into the pot. That will be about $130 million.A pay-per-view audience of three million at $89.98 would generate an estimated $270 million. Under the deal, according to The Times, cable companies and satellite providers will receive 30 percent to 40 percent of gross pay-per-view revenues, depending on the level of marketing each does.When the revenue is combined, the two fighters could divide around $300 million for a 12-round fight that will take less than an hour.“The demand is what’s driving the revenue,” Ellerbe said.There are more financial dynamics, but you get the point: A lot of money will be generated through this fight, money levels they would never have reached if they had fought six years ago.See why Mayweather says the timing is right? read more

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Friday AM Update Dense Smoke From Swan Lake Fire Expected To Linger

first_imgA low pressure weather pattern is setting up towards the weekend, which will likely bring cooler temperatures and precipitation as early as Friday night. Facebook0TwitterEmailPrintFriendly分享Update 7am: The new acreage of the Swan Lake Fire is at 162,179 acres and is now 27% complete. On the southwest corner of the fire, south of Sterling Highway, a portion of the line is now showing as complete. This means that fire managers feel safe that heat has been extinguished within 30-50′ of the fireline. Rocky Gilbert, the crews on the ground worked hard to pick up the slack: “We were able to get enough air to at least look at the stuff up Resurrection, but other than that not a good day for air support. It was a good day for our folks on the ground, on the west side of the fire protecting Sterling we still have over 100 firefighters. We are seeing some containment on that side and crews are feeling really good about it.”  Sterling Highway Update: 6am: The Sterling Highway remained open throughout the night with pilot car escorts between mile 71 and 40.  There is a chance Friday’s expected wind could cause the fire and smoke to pick up. The community of Cooper Landing does remain in a ‘Set’ status. Dan Nelson with the Borough Office of Emergency Management: “We are always going to do the most conservative action to keep the people safe, and that is why we remain at ‘Set’. A firefighter injured on Thursday has returned to his crew after being medevaced and evaluated. The firefighter was struck in the back of the head by a chunk of wood during clearing operations and lost consciousness. By Thursday evening, he has deemed suitable to return to duty. The southwestern corner of the fire experienced some increased activity near, but inside, containment lines.  Work will continue to cool this area as well as securing the perimeter northward to the Sterling Highway by extinguishing any remaining burning or smoldering fuels adjacent to the containment lines. Structure protection on the western flank is effectively in place.center_img An unmanned air vehicle, or drone, is currently being used on the south central area of the fire, above Skilak Lake. The drone is being used to assess the effectiveness of Wednesday’s burnout operations in this area. Fire managers wanted to use fire as a tool to bolster structure protection in the area. The Swan Lake Fire is estimated at 161,921 acres and remains at 20% containment. Heavy smoke continues to impact air operations on the fire. Currently, helicopters are unable to fly on the eastern flank of the fire in the Resurrection Trail area. The small amount of rain forecast won’t put the fire out but it may reduced fire behavior.  Fire Managers expect the road to continue to have pilot car escorts when its open and there is a possibility of long waits so be prepared with food and water. Swan Lake Fire Update: 6am: A Swan Lake Fire Community Meeting has been scheduled for Friday at 6pm, at the Sterling Community Center. You can tune into KSRM 920AM to listen live. The Sterling neighborhoods east of Feuding Lane and east of Adkins Road remain in a READY status. A READY notification means residents should be preparing for a potential evacuation should the threat level increase.last_img read more

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STUDENT SPOTLIGHT Wilmingtons Adam Riekstins Named To Deans List At Belmont University

first_imgNASHVILLE, TN — Adam Riekstins, of Wilmington, qualified for Belmont University’s Summer 2019 Dean’s List. Eligibility for the summer session is based on a minimum 9-hour course load over 10 weeks and a quality grade point average of 3.5 with no grade below a C.Belmont Provost Dr. Thomas Burns said, “This achievement indicates that these students have placed a high priority on their work at Belmont and have invested time and energy in their studies. It is our strong belief that consistent application in this manner will reap great benefits, which will equip them for a lifetime of learning and growing.”About Belmont UniversityRanked No. 6 in the Regional Universities South category and consistently named as a “Most Innovative” university by U.S. News & World Report, Belmont University is home to nearly 8,500 students who come from every state and more than 36 countries. Committed to being a leader among teaching universities, Belmont brings together the best of liberal arts and professional education in a Christian community of learning and service. The University’s purpose is to help students explore their passions and develop their talents to meet the world’s needs. With more than 95 areas of undergraduate study, more than 25 master’s programs and five doctoral degrees, there is no limit to the ways Belmont University can expand an individual’s horizon.For more information, visit www.belmont.edu.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com. Share this:TwitterFacebookLike this:Like Loading… RelatedSTUDENT SPOTLIGHT: Wilmington’s Adam Riekstins Travels The World For College CreditIn “Education”STUDENT SPOTLIGHT: 3 Wilmington Students Named To Dean’s List At Regis CollegeIn “Education”STUDENT SPOTLIGHT: Wilmington’s Scott Stenson Named To Dean’s List At Bentley UniversityIn “Education”last_img read more

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FCA pays Tesla big bucks to count EVs as its own to

first_img 0 In case you’ve been living under a rock for the last several centuries, it’s pretty easy to get out of certain kinds of trouble, so long as you’ve got a lot of money lying around. For Fiat Chrysler Automobiles, that pile of cash can ensure the automaker is complying with EU emissions regulations.FCA will pay Tesla a substantial amount of money to count Tesla’s cars as part of its own fleet in Europe. This move, which the Financial Times first reported on Sunday, is designed to allow Fiat Chrysler to remain in compliance with strict new European emissions regulations, despite the fact that its electrified-vehicle portfolio is awfully small. Of course, compliance doesn’t come cheap. The Financial Times’ report states that FCA will pay Tesla “hundreds of millions of euros” to make this happen. While these pooling arrangements do occasionally occur, most involve separate automakers under the same umbrella. What makes the Tesla-FCA tie-up unique, according to the report, is that the automakers are entirely separate with no other financial involvement between the two. This is allowed under the EU’s pooling rules, kind of like a carbon-trading scheme.Enlarge ImageFiat Chrysler gets to kick the can down the road, and Tesla gets a nine-figure payout. Everybody wins. AFP/Getty Images The Financial Times’ report points to data from UBS that said Fiat Chrysler had the best chances of failing to meet next year’s average emissions target of 95 grams of carbon dioxide per kilometer. FCA’s emissions last year were reportedly above the average. When the regulations are in full force, not being compliant could result in billions of euros in fines, the Financial Times said in its report, citing comments from Jefferies analysts.”FCA is committed to reducing the emissions of all our products. At the same time, we will optimize the options for compliance that the regulations offer,” a Fiat Chrysler spokesperson said in an emailed statement. “After all, the whole point of a CO2 credit market is to leverage the most cost-effective ways to reduce overall GHG emissions in the market. The purchase pool provides flexibility to deliver products our customers are willing to buy while managing compliance with the lowest-cost approach.” Basically, it’s cheaper to pay Tesla in this way than it would be to develop compliant cars and foist them upon a group of buyers that may not prefer them. Tesla did not immediately return a request for comment. The move will easily benefit both automakers. Tesla has already signaled that, given multiple factors in play, the company will likely miss profitability in Q1 2019 but hopes to be back in the black in Q2, and receiving a nine-figure sum from FCA would definitely help. As for Fiat Chrysler, this allows the automaker to kick the development can down the road a little longer, despite being a laggard in this regard already. Share your voice 2019 Maserati Levante GTS: Heart of gold Review • 2020 Jeep Gladiator review: The Wrangler pickup truck that really hauls More From Roadshow 57 Photos 2018 Mercedes-Benz E400 Cabriolet: How sweet it is News • 2020 Jeep Gladiator Launch Edition: The order books open today Post a comment 2020 Jeep Gladiator is business in front, truck bed in back Tesla Car Industry Electric Cars More about 2020 Jeep Gladiator Tags 2017 Chrysler Pacifica Hybrid: First hybrid minivan wins on fuel economy Fiat Chrysler Automobiles Fiat Tesla Chryslerlast_img read more

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CP Anjani Kumar holds meet on Bakrid security

first_imgPurani Haveli: City Police Commissioner Anjani Kumar on Thursday conducted a meeting with Special Branch officials in Purani Haveli office in view of forthcoming Bakrid Festival. He reviewed the situation in Old City and the arrangements made for the peaceful conduct of the festival in the city. He made several suggestions to avoid any untoward incidents. Additional CP (Crimes) Shikha Goel, Special Branch OSD Goverdhan Reddy and other officials were attended the meeting.last_img

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